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Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs

Fig 3

Methamphetamine plasma concentration (n = 4) vs time (hours) after third methamphetamine dose.

Test drugs caffeine (metabolised by CYP1A2) and midazolam (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0233010.g003