Using old antibiotics to treat ancient bacterium—β-lactams for Bacillus anthracis meningitis
Fig 2
Effect of compromising the BBB on the efficacy of Ampicillin treatment.
Naïve or pre-immune (Ampicillin 150+Vacc) rabbits were inoculated ICM with encapsulated Vollum bacteria and treated 6 hr post-infection with Ampicillin with the indicated dose (mg/kg) by IV or IV+ICM (Ampicillin 150+ICM). Survival and time to death are shown. Statistical significance P = 0.0779 for Ampicillin 150/300 vs. Ampicillin+ICM/PA.