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Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors

Fig 7

Comparative surface view analysis of group-II PAKs on the basis of MD simulation.

Surface view of (A and B) PAK4 and PAK4^Sep474, (C and D) inactive and active PAK4, rotated at 180°, (E and F) PAK5 and PAK5^Sep602, (G and H) inactive and active PAK5, rotated at 180°, (I and J) PAK6 and PAK6^Sep560, (K and L) inactive and active PAK6, rotated at 180°. Color codes are given in the Fig 4 legend.

doi: https://doi.org/10.1371/journal.pone.0225132.g007