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Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors

Fig 5

RMSD, RMSF and fluctuated residue plots for to explore the fluctuation and stability of PAKs group-II.

(A and B) RMSD and RMSF plots for PAK4 (light green) and PAK4^sep474 (maroon), (C and D) RMSD and RMSF plots for PAK5 (purple) and PAK5^Sep602 (deep pink), and (E and F) RMSD and RMSF plots for PAK6 (golden rod) and PAK3^Sep560 (dark green), respectively. (G) RMSF values of highly Fluctuating residues are plotted and indicated by the corresponding colors.

doi: https://doi.org/10.1371/journal.pone.0225132.g005