A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis
Table 1
MALT1 potency and selectivity profile across 156 common pharmacological targets (human unless otherwise stated) of mepazine, and tool Compounds 2 and 3, (data from Eurofins [26]), n.t. = not tested, pIC50 = negative logarithm of the concentration of compound that produce 50% inhibition/antagonism of the named target, pEC50 = negative logarithm of the concentration of the named compound that produces half the maximal agonistic effect of the named target protein.