Quantification of abnormal QRS peaks predicts response to cardiac resynchronization therapy and tracks structural remodeling
Fig 5
Examples of QRSp at baseline and follow-up in CRT responders and non-responders with baseline QRSd above and below 150ms.
QRSp Max results at baseline and follow-up for a single 10-beat window from (top left) a CRT responder with a QRSd ≥150ms, (top right) a CRT non-responder with a QRSd ≥150ms, (bottom left) a CRT responder with a QRSd <150ms, and (bottom right) a CRT non-responder with a QRSd <150ms. Irrespective of their baseline QRSd, the CRT responders have greater baseline QRSp Max values than the non-responders. At post-CRT followup, the QRS complexes of the responders become smoother and their QRSp decreases, while the QRS complexes of non-responders become more fractionated and their QRSp increase. Solid black lines demarcate the lQRS and dashed red lines demarcate the gQRS. Normal peaks are annotated with red diamonds, and abnormal peaks are annotated with green circles.