MicroRNA-582-5p suppresses non-small cell lung cancer cells growth and invasion via downregulating NOTCH1
Fig 5
NOTCH1 is up-regulated in NSCLC tissues compared with para-carcinoma tissues.
(A) The mRNA level of NOTCH1 in 30 paired NSCLC tissues and para-carcinoma tissues was detected with qPCR assay. The mRNA level of NOTCH1 is significantly higher in NSCLC tissues than that in para-carcinoma tissues. (B) The correlation between miR-582-5p and NOTCH1 is shown. (C) The mRNA expression of NOTCH1 in in the BEAS-2B immortalized human bronchial epithelial cell line and NSCLC cell lines (A549, NCI-H23, NCI-H358, NCI-H1975 and PC-9) was measured by using qPCR assay. Data are expressed as mean ± SD. *P<0.05 and ***P < 0.001 versus the normal tissues’ group or the BEAS-2B cell.