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Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex

Fig 5

Schematic representation of bispecific molecules targeting HER2.

A. Bispecific antibody with knob-into-hole Fc. B. Bispecific molecules with engineered hinge region of IgG3. C. Bispecific molecules connected by a dimeric coiled coil.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0216095.g005