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Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer’s disease

Fig 1

The design of new analogues based on the potent, first generation molecule, donepezil.

Here, D1 was designed from donepezil, while others (D2 to D10) are based on the basic structure of D1.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0211935.g001