SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
Fig 5
Sirt5 KO ameliorates cardiac dysfunction caused by TAC.
(A-F) Left ventricular cardiac functional parameters between male Sirt5 KO mice and WT littermates at 5 weeks after TAC surgery (n = 6–10 animals per group), including left ventricular internal diastolic diameter (LVIDd) (A), left ventricular internal systolic diameter (LVIDs) (B), left ventricular end-diastolic volume (LVEDV) (C), left ventricular end-systolic volume (LVESV) (D), left ventricular ejection fraction LVEF% (E), and left ventricular shortening fraction LVFS% (F). Data are shown as mean ± SD of at least 3 independent experiments, one-way ANOVA. *denotes the P< 0.05 and **denotes the P < 0.01 for the indicated comparisons. n.s. = not significant.