Knockdown of PTOV1 and PIN1 exhibit common phenotypic anti-cancer effects in MDA-MB-231 cells
Fig 3
Silencing of PIN1 and PTOV1 alter cell morphology, apoptosis, and intracellular ROS production.
(A) Representative images of cells transfected with the siRNAs after 72 hours and stained with Hoechst 33342. (B) Microscopic evaluation of intracellular ROS production in each group after 72 hours using CM-H2DCFDA. Images were captured using Nikon fluorescent microscope, right panel shows the graphical representation of the ROS production in different set of experiments. *** represents the significant difference from scramble (p< 0.001).