Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin
Fig 5
Pharmacodynamics of One Generic and the innovator of imipenem-cilastatin against the wild-type strain S. aureus GRP-0057 in the neutropenic mouse thigh infection model.
The data shown in the graphs is pooled from 5 independent experiments comparing simultaneously both products, in which the generic was consistently less effective than the innovator.