Improved multilineage human hematopoietic reconstitution and function in NSGS mice
Fig 7
Mature T cells expand similarly in NSG and NSGS as shown by GVHD models.
A) Individual mouse weights over time after tail vein injection of adult PB MNCs. NSG (blue lines) and NSGS (red lines) experience weight loss with similar kinetics. Conditioned mice (filled boxes) show weight loss before non-conditioned mice (open boxes). B-C) Survival of the mice in panel A. D) Levels of CD3+ T cells in mice at 2 weeks. E) Levels of CD4 and CD8 cells at 2 weeks. F) Ki-67 staining reveals no changes in the cycling of either CD4 or CD8 T cells between strains. G) Representative plot used to generate panel F.