Improved multilineage human hematopoietic reconstitution and function in NSGS mice
Fig 5
NSGS have increased sensitivity to SRCs.
A) Whole BM from primary engrafted NSG and NSGS mice (15 weeks) was used for secondary transplant into NSGS mice. Only NSG BM had detectable SRC activity at 8 weeks after transplant. B) BM from primary NSG mice (15 weeks) was used for paired secondary transplant into NSG and NSGS mice. The NSGS mice engrafted significantly better at 8 weeks. C) A series of UCB CD34+ preparations were engrafted into non-conditioned NSG and NSGS and BM engraftment was measured at 10 weeks. Asterisks indicate p value less than 0.05 by Student’s T Tests.