Improved multilineage human hematopoietic reconstitution and function in NSGS mice
Fig 4
Reduced CD34+ cells in BM are myeloid skewed.
A) Averages and B) representative FACS analysis of UCB-engrafted BM demonstrating higher CD33+ and lower CD19+ co-staining on CD34+ cells from NSGS mice engrafted for 15 weeks. C) Primitive CD34+CD38- cells were also significantly reduced in NSGS BM (flow example also shown in B). Asterisks indicate p value less than 0.05 by Student’s T Test.