Periodontal regenerative effect of enamel matrix derivative in diabetes
Fig 5
Micro-computed tomographic (CT) analysis.
(A) Representative three-dimensional volume images of new bone formation by micro-CT after 28 d in the four groups [control without the enamel matrix derivative [EMD] and without the cement enamel CE(-); control with EMD, CE(+); diabetes without EMD, DE(-); and diabetes with EMD, DE(+)]. Defects in the control and DM groups were assessed by micro-CT. Less regeneration was observed in the DE(-) and DE(+) groups than in the CE(-) and CE(+) groups. More newly formed bone was observed in CE(+) and DE(+) than in CE(-) and DE(-). (B) Quantitative analysis of new bone formation by micro-CT in each group. (1) Bone volume, BV; (2) cancellous bone volume, CBV; (3) bone mineral density, BMD; and (4) cancellous bone mineral content, CBM were compared between groups. Measurements were independently made by two blinded examiners (T.M. and D.K.), and the data were analyzed. Data are presented as means ± SD (n = 24). *p < 0.05 (two-way repeated-measures analysis of variance). NS, not statistically significant.