A comparative structural analysis of the surface properties of asco-laccases
Fig 6
Dimeric MtL assembly observed in the crystal.
A) Surface representation with protomers shown in black and white, respectively. In this dimeric arrangement, the only entrance to the T1-pocket is through the conserved, (putative) substrate entrance channels [8] indicated in yellow. B) Zoom in on the dimer interface near the T1-pocket. Cartoon representation with selected residues shown as sticks. To mimick the position of a putative ligand, 2,6-DMP (dotted surface) from the MaL complex (3FU7) was superimposed on each monomer separately. In the MtL structure, the Phe427 docks into the T1-pocket of the other protomer and thereby hampering substrate binding.