Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells
Fig 2
miRNA 14q32.31 cluster is deregulated in association with replicative senescence.
(A) Bar graph shows log fold-change expression for the miRNAs in the 14q32 chromosome region that were deregulated in short-term (PS) versus long-term (PL) cultured adult ADSC samples (n = 2 biological replicates in both cases; mean ± SEM). (B) Relative quantitation (see extended methods in Supporting information for details) of selected miRNAs for array validation in adult (n = 3 biological replicates) and pediatric (n = 2 biological replicates) hADSCs; data represent mean ± SEM (* p <0.05; one-tailed paired t-test).