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Medial septal cholinergic mediation of hippocampal theta rhythm induced by vagal nerve stimulation

Fig 9

The effect of MS McN-A343 injection on VNS-induced HPC field potential and related power-frequency (FFT) histogram.

(A) VNS is marked with a horizontal line. The parameters of VNS are marked below this line. Arrows indicate the power-frequency histograms calculated from analog examples of hippocampal field potentials taken pre-injection of McN-A343 (control), 15 and 60 min post-injection of McN-A343 during 10 s VNS. Calibration: 1 s, 150 μV. (B) Statistical analysis (Mann-Whitney U test) of mean ± SEM power and frequency (VNS(1) vs VNS(2), and VNS(1) vs VNS(3)).

Fig 9

doi: https://doi.org/10.1371/journal.pone.0206532.g009