Immune diversity sheds light on missing variation in worldwide genetic diversity panels
Fig 3
The common HLA alleles that are missing in the 1,000 Genome Project panel define a worldwide distribution with variable frequencies that range from low (1–2.5%) to high (>10%).
A. Worldwide distribution of the populations harboring alleles that are missing in the 1,000 Genomes Project. Colors and size of the circles correspond to the number of common alleles observed in each population (scale on the bottom left corner). The map was generated using the ggplot2 package in R [16] and the world database. B. Geographical distribution of the alleles that are missing in the 1,000 Genomes Project. For each region, the number of distinct alleles is given together with their maximum frequencies.