Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors
Fig 5
Representative calcium traces for NKA, substance P, [Lys5,MeLeu9,Nle10]-NKA(4–10) and [β-Ala8]-NKA(4–10) using human recombinant NK2 and NK1 receptors.
Compounds were tested at the EC50 concentration. Data are expressed as relative fluorescence units (RFU) measured over a period of 200 seconds. A: NK2 receptors, B: NK1 receptors.