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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

Fig 23

Chemical synthesis of tertiary alcohol-linked cyclodextrin prodrug.

Reagents and conditions: (a) Et3N, succinic anhydride, DMAP, N-hydroxysuccinimide, toluene, 120°C, 54%; (b) α-cyclodextrin, EDCI, DMAP, rt, 22%.

Fig 23

doi: https://doi.org/10.1371/journal.pone.0203567.g023