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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

Fig 11

Unbound colon, liver, and blood concentrations of compound 1 in healthy and DSS mice at 11 h (Day 14 DSS) or 12 h (Day 1, Day 7 Healthy) after multi-day dosing of 2.

Also shown are unbound concentrations of compound 3 in DSS mice. Cellular EC₅₀ corrected for binding in 10% FBS is represented by a dashed blue line (compound 1) or a purple line (compound 3).

doi: https://doi.org/10.1371/journal.pone.0203567.g011