Nanoplasmonic pillars engineered for single exosome detection
Fig 4
Subsampled LSPRi time series from a 400 nanopillar array (background subtracted).
The blue, green and red squares on the inset images encompass the subsampled nanopillars, the average response of which is plotted in the corresponding color. For all panels, 1 × 105 exosomes/ml was introduced at t ~ 1200 sec. (A) Spatially averaged time course of the entire 20 × 20 array (144 μm2) in blue. (B) Spatially averaged time course of the entire 20 × 20 array (144 μm2) and the 4 × 4 subarray (5.8 μm2) outlined in green (C) Spatially averaged time course of the entire 20 × 20 array (144 μm2), the 4 × 4 subarray (5.8 μm2) outlined in green and the 4 × 4 subarray (5.8 μm2) outlined in red. (D) Spatially averaged time course of the entire 20 × 20 array (144 μm2) and a separate control experiment (black data) on the same array functionalized with the IgG control antibodies.