Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition
Fig 1
Analysis of cell viability after 72 h treatment with Hsp90 inhibitors NVP-AUY922, BIIB021 and AT-13387.
(A) Toxicity of NVP-AUY922 and BIIB021 in MCF7 cells did not reach 50% in 72 h. All experiments were repeated 4 times. (B) Comparison of IC20 of Hsp90 inhibitors in breast cancer cell lines. (C) The comparison of sensitivity based on p53 status, Her2 (ErbB2) status, and subtype of breast cancer.