Monocyte depletion attenuates the development of posttraumatic hydrocephalus and preserves white matter integrity after traumatic brain injury
Fig 3
Clodronate-mediated monocyte depletion attenuates ventricle enlargement but not lesion size after traumatic brain injury.
A) Representative axial T1W MR images of a TBI/Clodronate treated mouse (a-c) and a TBI/PBS treated mouse (d-f) on post-TBI days 1, 7, and 14. ‘Lesion area’ is outlined in RED. B) Representative coronal T1W MR images of the corresponding TBI/Clodronate treated mouse (g-i) and TBI/PBS treated mouse (j-l) at 1, 7, and 14 days post-TBI. The hyperattenuating area denotes the progressive enlargement of ventricle size over time. C) No significant difference in lesion size was detected at any time point between monocyte-depleted and sham-depleted mice (5 ± 1.1mm3 vs 7.3 ± 1.06mm3; p = 0.4). D) At 14 days post-TBI clodronate depletion markedly attenuated ventricle enlargement (5.3 ± 0.9mm3) as compared to sham-depleted mice(13.2 ± 3.1mm3; ** p = 0.02).