Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)
Fig 4
Total recovery of [3H]-lamivudine from urine (A) and bile (C), and its accumulation in renal (B) and liver (D) tissue at 240 minutes after i.v. administration with or without co-administration of efavirenz (2.53 mg/kg) or cimetidine (a control inhibitor of the OCT and MATE transporters; 60,6 mg/kg). Data are shown as means ± SD (n = 5) and were analysed using one-way ANOVA followed by Dunnett`s multiple comparison test * P ≤ 0.05, *** P ≤ 0.001, n.s. not significant.