Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies
Fig 3
Curcumin induces spermine catabolism through spermine oxidation in AGS cells.
AGS cells were treated for 48 hours and analyzed for SMOX (A) and SSAT (D) mRNA expression via qRT-PCR; (B-C) SMOX and SSAT protein levels by Western blot; and (E) SSAT enzyme activity. Graphs depict the mean values of at least 2 individual experiments, each measured in triplicate. Error bars = SEM; *p < 0.05. A representative western blot is presented in (C).