A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes
Fig 5
Amide and alkyl regions of the 1H NMR spectra of peptides 3 and 5–10.
Their different content of pairwise installed d-amino acids corresponds to the respective zigzag shapes depicted in Figs 1 and 2. The peptides are listed according to the characteristic highfield shift of L12-Hδ (right blue ribbon) which identify the completely folded hydrophobic cluster and correlates with the downfield shift of E4-NH (left blue ribbon). R9-NH is in all cases the most shielded amide proton (red ribbon; 600 MHz, 280 K, 50 mm potassium phosphate buffer (pH = 7.0)/D2O 9:1).