iMapSplice: Alleviating reference bias through personalized RNA-seq alignment
Fig 2
Aggregated reference allelic ratio distribution of different methods on RNA-seq datasets from individuals NA12812, NA12749, NA07056, NA06994, and NA12275.
(A) Comparison between iMapSplice-phased and “Ref-based” methods (MapSplice, HISAT2, and STAR); (B) Comparison between iMapSplice-phased and “Mask-based” methods (MapSplice MASK, HISAT2 MASK, and STAR MASK); (C) Comparison between two variants of iMapSplice and “SNP-aware” methods (HISAT2 SNP and HISAT2 POP); (D) Summarized comparison in terms of mean and skewness for reference allelic ratio distributions, and number of SNPs covered by at least ten reads.