Image and motor behavior for monitoring tumor growth in C6 glioma model
Fig 3
Tumor growth analysis by image.
(A) Coronal plane of T2-weighted MRI images, at base; (B) C6 glioma cells injection localization according to coordinate (2.0;2;0;2.5 mm); (C–F) Coronal plane of T2-weighted MRI images at days 7, 14, 21, and 28 after tumor brain induction ().; (G–H) Microscopic and macroscopic images at base and (I–J) at the day 28 after tumor induction; (K–N) in vivo 2D-bioluminescence imaging at days 7, 14, 21, and days after tumor induction and corresponding brain (ex vivo) with bioluminescence signal after 10 min of brain extraction; (O) MRI volumetric results at each time point. (P) The mean tumor volume by MRI is plotted against the mean BLI in vivo signal at four points of analysis (n = 4 per group), and the Pearson correlation coefficient (r = 0.96) between both results plotted and (Q) bioluminescence tumor growth results of each time point (n = 4 per group).