Neural activity and fundamental learning, motivated by monetary loss and reward, are intact in mild to moderate major depressive disorder
Fig 5
Significant activations for key contrasts, on which region-of-interest analysis was based, replicated previous findings.
a. Go > No-Go contrast showed significant bilateral midbrain (crosshairs), caudate, insula, primary motor and supplementary motor clusters (FWE p<0.001). b. No-Go > Go contrast, i.e. areas activated when action was to be withheld, showed highly significant bilateral inferior frontal, medial prefrontal, posterior cingulate and hippocampal clusters, as well as a prominent left parieto-occipital cluster (all FWE p<0.001).