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The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide

Fig 2

Determination of serum hormone levels.

A. Compared with the control group, serum levels of E2 was significantly decreased in POF, CH +, CH + + groups (* P <0.05). Compared with the POF group, serum levels of E2 was significantly increased in HPE, CH++ and CH+++ groups (* P <0.05). B. Compared with the control group, serum levels of FSH was significantly increased in POF, CH +, CH + + and CH+++groups (* P <0.05). Compared with the POF group, serum levels of FSH was significantly decreased in HPE, CH++ and CH+++ groups (* P <0.05). C. Compared with the control group, serum levels of LH were significantly increased in POF, CH + and CH + + groups (* P <0.05). Compared with the POF group, serum levels of FSH was significantly decreased in HPE, CH++ and CH+++ groups (* P <0.05). D. Compared with the control group, serum levels of Progesterone was significantly decreased in POF, CH + and CH + + groups (* P <0.05). Compared with the POF group, serum levels of Progesterone were significantly increased in HPE, CH++ and CH+++ groups (* P <0.05).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0201136.g002