Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
Fig 2
Activation of TREK-2 currents by ostruthin.
(A and B) Run-up and activation of TREK-2 channel currents. Whole cell TREK-2 channel currents expressed in 293T cells showed a run-up, which ceased within 3 min. Ostruthin, which was applied 5 min after the whole-cell access, activated TREK-2 channel currents at 100 μM. The activated current was inhibited by bupivacaine nearly completely. (C) The concentration-response curve of ostruthin on the TREK-2 currents. The EC50 was found to be 3.7 mM. (n = 5).