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Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Fig 7

Effect of gallein on human M1 and M2 macrophages in vitro.

(A-D) Changes in gene expression of macrophage phenotype markers after gallein treatment (qRT-PCR from n = 3 experimental replicates). Data are normalized to expression of GAPDH. Control groups in each phenotype are cells without gallein treatment. Data are shown as Mean ± SEM. *p<0.05, **p<0.01, ***p<0.001 vs Control.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0200697.g007