Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Fig 2
Effect of gallein on BW, HW and echocardiographic parameters.
(A-G) BW, body weight; HW, heart weight; LVDd, left ventricular dimension in diastole; LVDs, left ventricular dimension in systole; FS, fractional shortening; EF, ejection fraction; group Normal, age matched untreated rats; group EAM, rats with experimental autoimmune myocarditis treated with vehicle; group EAM+G10, rats with EAM treated with gallein given orally at 10 mg/kg/day. ***p<0.001, **p<0.01 and *p<0.05 vs Normal; ##p<0.01 and #p<0.05 vs EAM. Results are presented as mean ± SEM, n = 4–5.