Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors
Fig 5
Immature DCs do not mediate ADE of ZIKV infection.
(A) Immature DCs were infected with ZIKV (MOI 2) in the presence or absence of serially diluted DENV immune serum (D1-E01) or DENV-naïve serum (Naïve-01). 48 h post-infection, cells were harvested and intracellularly stained with an anti-E antibody and subjected to flow cytometry analysis. A representative infection panel of two independent experiments was presented. (B) Supernatants from ZIKV-infected immature DCs were collected and inoculated to Vero cells for 2 days. Vero cells were collected and intracelullarly stained with an anti-E antibody for flow cytometry analysis. Data shown were representative results of three independent experiments.