BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Fig 10
Sez6L co-staining with BACE1 reveals their increased immunoreactivity in the cell body of NPC1 vs. wt mouse primary cortical neurons.
Representative images of primary mouse cortical neurons stained with Sez6L antibody co-stained with BACE1. In NPC1-/- (NPC1) cortical neurons, in contrast to NPC1+/+ (wt) neurons, we observed an increased punctate staining of Sez6L in the cell body and in the neuronal processes. The cell body co-staining of Sez6L and BACE1 was enhanced in NPC1 vs. wt neurons (indicated by arrows).