BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Fig 9
NPC1 mouse primary cortical neurons show profound Sez6L punctuate staining in neuronal processes.
Representative images of primary mouse cortical neurons stained with Sez6L antibody and endocytic markers: early endosome antigen (EEA1) and transferrin receptor (TfR). Immunoreactivity of Sez6L in NPC1+/+ (wt) cortical neurons was detected in both soma and neuronal processes. Upon NPC1-loss and cholesterol accumulation in NPC1-/- (NPC1) cortical neurons Sez6L showed more enlarged punctate staining mainly in TfR-positive vesicles in the soma and in neuronal processes (indicated by arrows).