BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Fig 5
BACE1 distribution is similar between 10-weeks old NPC1 vs. wt mouse brains.
BACE1 (green) is intensely staining mossy fibers in the hippocampus of both wt and NPC1 mice. DAPI (blue) was used to counterstain all nuclei. There may be a slight decrease of BACE1 immunoreactivity in NPC1 mouse brains most likely due to profound neuropathological processes at this stage.