BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Fig 2
The levels of BACE1-generated soluble APPβ fragments are increased in the cortex of 4-weeks old NPC1 vs. wt mice.
(A) Western blot analysis of soluble APPβ (sAPPβ) and actin (Actin-DEA) protein levels in DEA fractions of the cortex collected from 4-weeks old wt (NPC1+/+; N = 6) and NPC1 (NPC1-/-; N = 6) mice. A standard protein lysate (S) was included twice on each gel. (B) A graph representing quantified protein signals for soluble APPβ (sAPPβ) in the cortex of 4-weeks old animals which were normalized against actin protein levels (Actin-DEA).