The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases
Fig 7
Galardin docked into the catalytic site of thermolysin, pseudolysin and auerolysin.
The figure shows close ups of the active site region with the compound structures (xsticks), secondary structure elements and the most important amino acids for ligand binding (xsticks) indicated. Colour coding of atoms of amino acids and ligands: oxygen; red, nitrogen; blue, hydrogen; white, carbon atoms of ligands; yellow, carbon atoms of amino acid side chains; grey, the zinc ion; light blue.