The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases
Fig 3
Inhibition of MMP-14 by galardin (A, B) and compound 1b (C, D). The inhibition constant Ki and [MMP-14] in assay were obtained from dose response plots vi/v0 vs [I] using the Morrison Eq (2) (A, C) and Henderson plots (B, D). In all plots, [MMP-14] was twice as high for experiments labelled (□) as for those labelled (●). The [S] is 5.0 μM except in the experiment in (B) labelled (□) where it is 10.0 μM. Shown in the figures is also the obtained Ki and [E] values (mean ± SD), in addition to the regression coefficient r2 and the number of individual assays (N) for each curve.