Predicting position along a looping immune response trajectory
Fig 2
Schematic demonstrating use of symbolic aggregate approximation (SAX) in identifying candidate phase-shifted gene pairs.
(A) Selected large-ranged genes were converted from numerical log2 form to SAX form. For each gene, we then computed a search pattern by shifting the SAX form by T/4 time points (T = total number of time points sampled) (B) Determining phase-shifted gene pairs based on SAX search pattern match; Genes 1 and 2 match the pattern while Genes 1 and 3 do not. (C) Genes that match the search pattern trace a loop (left) while mismatched genes do not (right).