Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor
Fig 5
Nrf2 activation is hormonally-regulated.
A. (left) Nrf2 activation is suppressed by testosterone and activated by estradiol. Effects on the Nrf2 biomarker were examined after treatment with estrogen, testosterone, or dihydrotestosterone in the indicated studies. Biosets were derived from GSE13265 and GSE13388. (Right) The same biosets were examined for effects on STAT5b. B. Nrf2 is activated by ethinyl estradiol in male mice. Mice were treated with ethinyl estradiol for 7 or 28 days at the indicated doses and then evaluated for effects on Nrf2 (left) or STAT5b (right). Biosets were derived from GSE84590.