New 1,3-benzodioxin-4-ones from Synnemapestaloides ericacearum sp. nov., a biosynthetic link to remarkable compounds within the Xylariales
Fig 5
A) Proposed biosynthesis of maladoxin from the oxidation of dihydromaldoxin by a Xylariales fungus (unidentified Xylaria sp.; adapted from Adeboya et al. 1996). B) Proposed biosynthetic scheme of chloropestolides from P. fici from the oxidation of the diphenyl ether pestheic acid to maladoxin followed by the Diels-Alder addition of iso-A82775C (adapted from Liu et al. 2013). C) Proposed biosynthesis of synnemadoxin A (1) by Syn. ericacearum from the oxidation of synnemadiacid A (3), analogous to the schemes proposed for maldoxin from and unidentified Xylaria sp. (Xylariales) and P. fici.