Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis
Fig 5
Behavioral assessment for anxiety at 60 days after sham or endometriosis surgery.
Rats that received sham surgery did not receive any treatment (n = 10). Rats in the endometriosis groups received antalarmin (n = 20) or vehicle treatment (n = 20) during one week after surgery until 53 days before behavioral testing. (A and B) All animals were tested in the open field or (C and D) the elevated zero maze. (A) In comparison to sham, we observed a significant decrease in locomotor activity of the group that received antalarmin. (B) However, time spent in the center of the open field was not different between groups. (C) In the elevated zero maze, a significant decrease in locomotion was observed for rats that had endometriosis as compared to sham, regardless of the drug treatment. (D) Rats with endometriosis, regardless of drug treatment, showed a trend towards spending less time in the open segment of the zero maze as compared to sham group. * represents p< 0.05 compared to sham.