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Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters

Fig 1

Tryptophan metabolism through the kynurenine pathway.

Tryptophan metabolism proceeds through kynurenine in multiple branches, which includes the formation of KYNA by the KAT enzymes.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0196404.g001