Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive
Fig 4
Effect of EP055 on rhesus macaque (Macaca mulatta) sperm parameters.
Closed circles represent percent normal motility and bars represent semen levels of EP055 in A and B. (A) Correlation between EP055 semen levels and normal sperm motility after a single low dose (75–80 mg/kg) # show the significant increase in EP055 semen levels compared to untreated (Kruskal-Wallis analysis, p < 0.05). (B) Correlation between EP055 semen levels and normal sperm motility after a single high dose (125–130 mg/kg) # show the significant increase in EP055 semen levels and * show the significant decreases in motility by Kruskal-Wallis analysis (p< 0.05, compared to untreated). (C) Photograph of sperm from male 28043 at 28–30 hrs after the high dose showing clumping. See S1 Movie. (D) Photograph of sperm from male 28043 at high dose recovery (18 days post-infusion) showing normal spacing at the same sperm density. See S2 Movie. Results shown are for the mean ± SEM of n = 4 animals. Fertile and sub-fertile indices of motility are based on human clinical parameters [20].