Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive
Fig 2
EP055 time course and tissue levels in Macaca fascicularis after a single i.v. injection.
(A) Plasma half-life determination after infusion of a single dose (n = 3 males; 1mg/kg). t1/2 = 10.6 ± 2 minutes. (B) Testis tissue levels (n = 2 males per time point; 63.25 mg/kg) at 2 hr are statistically different from 2 hr epididymis levels (p < 0.05) by One-way ANOVA. The differences at 6 hr were not significant. There was no difference in the ratio of E/T at either time point. (C) Total μg of compound per tissue shows no significant difference between 2 hr levels and 6 hr levels (p < 0.05) by One-way ANOVA.